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SMART - MRI Guided Adaptive Radiation Therapy
Prostate Cancer | Last Active: Oct 4, 2025 | Replies (12)Comment receiving replies
@jeffmarc
Age 67. Extremely active.
On Active surveillance since 2020.
2025 Biopsy results attached.
Gleason score 3+4 w potential extra prostatic extension raising NCCN risk to unfavorable intermediate.
Progression of cancer continued to worsen in each annual mris and biopsy.
Psa increased from 3ish in 2020 to 6 in 2025.
Decipher .88 - high risk.
Polaris 3.2 - low risk
PET - no outside spread
Hope this helps!
I’m no expert, but happy to share if helpful.
Replies to "@jeffmarc Age 67. Extremely active. On Active surveillance since 2020. 2025 Biopsy results attached. Gleason score..."
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@tjp1958
It definitely looks like the cancer has spread beyond the prostate. I would imagine that if they’re doing MRI guided radiation, they would’ve hit the area that looked like it had spread to. You could ask the RO If that did happen just to confirm that they did cover that area and you Have “clean margins” as far as radiation is concerned.
That would be the only thing I would be concerned with. You are all 3+4 or less And nothing else that is looked for to be possible to escape radiation is in your biopsy.
Overall, it looks real good.
AI Overview
In a prostate cancer biopsy report, "tumor extends into loose fibroconnective tissue at the end of the core" means the cancer has likely spread beyond the prostate gland's boundaries. This is also known as extraprostatic extension (EPE) or extracapsular extension.
Here is a breakdown of the key terms:
Loose fibroconnective tissue: The tissue just outside the prostate. A pathologist views this material at the end of the biopsy sample, which marks the outer edge of the prostate.
Extends into loose fibroconnective tissue: The cancer cells are seen invading this tissue, which suggests they have broken through the prostate capsule and spread beyond the gland.