Hi Jake. I have taken Venlafaxine, 150mg, off and on for about 25 years. Have tried many other antidepressants because missed having good sex, but the others have the same side effects of numbing sexual pleasure, but Venlafaxine (Effexor) is best for my anxiety issues and is an acceptable trade off. Presently I am a week into lowering my dose to 75mg while adding Mirtazapine, because I read it works differently with no sexual side-effects. I have also been taking CBD/CBN oil, which helps reduce the side-effects of the transition. I am near 80 yrs old and hope Mirtazapine can replace the Effexor eventually. Wish me luck!