Sorry to hear about your surgery being unsuccessful. I was able to go 3 1/2 years after surgery before my PSA started rising.

You should be aware of that Orgovyx is ADT (Antigen deprivation therapy) And it essentially drops your testosterone down to below 20, And frequently much below that. There are multiple different ADT products that all do the same. As a result, you have a lot of side effects. One of them is that you lose the desire to have sex, and maybe even to have an erection and an orgasm

When my PSA started rising they put me on a 6 month Lupron shot (another ADT) And two months later, I had radiation. That worked for 2 1/2 years at which point my PSA started rising and I was put on Lupron on which I have now been for almost nine years. I did switch from Lupron To Orgovyx Two years ago, But it essentially works the same as Lupron.

Actually, you should take calcium citrate 500 mg twice a day. That’s recommended for bone health. If you take 600 mg 100 of it gets thrown away because your body can only absorb 500 mg at a time.

If you take Prilosec, you should take Orgovyx at least six hours later Or it can make side effects worse.

Due to their different mechanisms of action. ADT which includes Orgovyx, Firmagon, Lupron, Eligard, Prostap, Camcevi, Lucrin, Zoladex, Trelstar, Pamorelin, and Decapeptyl can cause numerous side effects. Actually due to a lack of testosterone.
Hot flashes
Fatigue
Muscle deterioration
Bone weakening
Brain fog
Depression
Weight gain
Difficulty in breathing

Not all of these side effects occur to everyone on the drugs. Most of them are just things you have to be aware of and circumvent. I walk on the track twice a day, 1 mile at least, to help prevent bone weakening, fatigue and muscle deterioration. I also go to the gym three days a week (usually) and spend an hour with all different types of weight exercises. One thing that happens is people get a beer belly from the muscle deterioration, I do a lot of sit-ups to offset that.

Some people get depression but it is not common. It is easily treatable, according to people that have reported it on here and on Online Meetings I have participated in. If he has that problem Come back and ask for help, Or see a psychiatrist about doing something to relieve the depression.

Some people get no hot flashes at all. Others only have a few hot flashes and they are very minor. I had severe hot flashes for the first year on Lupron. As a hot flash was hitting I would feel a lot of fatigue. After a year, my oncologist prescribed a depo-provera shot every three months and it really stopped those hot flashes on Lupron. There are other hormones that can do this, speak to your doctor. I know one person that says eating tofu every day really controlled his hot flashes, another person in this forum said the same thing. Tofu does have properties similar to endocrine hormones but a lot weaker. Can’t hurt to try it. Seems they ate it daily.

According to a doctor that spoke to a recent webinar, all people on ADT should be taking bone straighteners. I took Fosamax for six years and I’m now on Zometa. That along with calcium taken daily helps keep your bones strong. Ask your doctor about this.

I have never gained any weight while on ADT. I get on the scale every morning and base what I eat on what I weigh. Skip lunch at times.

Hopefully you have a minimal number of side effects.