I have been taking Tymlos since January 2024, after I tripped and fell and ended up with a compression fracture at L1. I've taken Fosamax and Prolia in the past. I've had only one DEXA since starting Tymlos, in February 2025, and it showed significant improvement in my spine, where it usually works best, and very little change elsewhere. I will go off it in January and what comes next is unclear.

As for side effects, I found them completely manageable. At first I took the shot early in the evening. I would feel a bit nauseous sometimes and occasionally my heart would race for a few seconds. The nausea passed in an hour or two, wasn't awful, but was certainly unpleasant. I switched to taking the shot right before I got into bed at night, and that resolved the issue, even though I stay up to read for easily an hour or more after I get into bed every night. I have no idea why this makes any difference, but it does, at least for me.

As for the shot itself, it is absolutely nothing once you get past the idea that you're giving yourself a shot. It's a very short, very thin needle, and I usually don't feel it at all. Once in a while depending on where I inject I feel a slight prick, which goes away the second I withdraw the needle.

Everyone is different, and no one can tell you what your experience will be. But for my money it's well worth the try. My spine is now barely osteoporotic (t score -2.6), and I'm hoping it will have improved even more during the second year.

Good luck to you. Osteoporosis is the most frustrating medial problem--every solution is fraught with potential drawbacks!