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@scottbeammeup You're facing the classic post-PCa treatment dilemma.

If this were a pre-2015 year I suspect everyone - your oncologist, sexual health doc and endocrinologist - would all oppose any TRT. That's just the way it was.

However...it's 2025 and there have been many favorable studies during the last 10 years on varying applications of testosterone for PCa patients. My recommendation would be to do two different types of AI research during the next several weeks on this issue:

- One AI research question should include everything in your PCa background and statistics. Provide lots of details that are particular to you. Then ask the question, "Based on all available clinical studies, pre-clinical reports and other scientific information, should utilizing testosterone replacement therapy represent a significant concern for this former PCa patient at this time?"

- A second AI research question should duplicate the first AI research question, but also include an extra sentence which states, "Please limit your consideration of clinical and scientific reports issued after 2014."

Why do this??? Because this is what I did for myself and I found the results to be eye opening:

- AI research question #1 was skeptical and highly reluctant to embrace TRT.

- AI research question #2 was significantly more positive, concluding it would be reasonably safe to resume TRT in my situation based on current scientific evidence. Plenty of supporting analysis, footnotes and source materials were included as part of the AI report too.

Gosh -- it was so impressive. I think the AI world is ushering us into the dawn of a new medical era. Patients are becoming empowered.

It's obviously your call on what to do and how to proceed. Nonetheless, you can count on me cheering for you.

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Replies to "@scottbeammeup You're facing the classic post-PCa treatment dilemma. If this were a pre-2015 year I suspect..."

@kenk1962 This was really helpful. The data showed LESS mortality in those treated with TRT post PC with low PSA than those who were not. "The best modern evidence does not show higher recurrence rates in men on TRT. In fact, some series tilt toward better outcomes. That doesn’t mean it’s a free pass—you still need PSA checks—but the fear of “pouring gas on the fire” is not supported by the data."