Where is your outlet obstruction? Like where your stomach meets your small Intestines?????? Have you had a CT or MRI, an EGD and Colonoscopy and a Sitz study( tells how long it takes to pass the radiopaque pill). There are more test also. I have to take miralax mixed with magnesium citrate every night at 7:30 pm and without fail I use Linzess 290 mg daily at 5 am with six glasses of very warm water. Half hour later I eat breakfast. I usually have a BM 45 min later. I also drink lots of water and eat high fiber and chew my food well. I also take digestive enzymes. If you do alcohol or any drugs or even meds for nerve pain that will hault motility. I have severe arthritis in hands and low back and some nerve compression in back. Dr wanted me to take gabapentin( neurontin) 600 mg three times a day. Three days on that and I was major stoned and I didn’t have a BM until I was off of it for a week. Now I only take 100 mg in the morning and Celebrex . I’m sort of glad my intestines are slow because it has prevented me from using pain meds and becoming addicted. I would go ahead and take the Amitiza as instructed but maybe in addition try a bottle of Mag Citrate with some ducolax. Check with your Dr first!!!! It can cause major dehydration and electrolyte imbalance and other problems but they use this to clean people out for colonoscopies. Drink Gatorade after doing this. Only do this as instructed by your Dr. Also eat a soft diet, low residue until you get unblocked, or just liquids, but if your completely blocked you will have nausea, vomiting, pain, distention don’t eat anything and go to ER. I also use an abdominal massager before and after every meal. If you truly have an obstruction with multiple ER visits you need to have more test and possibly time for a GI surgeon. Not always the answer and if they remove the part that’s blocked, scar tissue can form and other issues can arise but sometimes it solves the problems. Drs today are a different breed than they were in the past( dumbing down), lower standards. Can’t critical think without a million test, no ability to listen to the patient and evaluate signs and symptoms. It is “ok” for you to be proactive about your issue; you know your body.