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Negative Turn in a Long Journey
Pancreatic Cancer | Last Active: Mar 26 2:09pm | Replies (107)Comment receiving replies
@vannkraken My dosage is 1200 mg BID. I'm in the 1B phase and taking what was established to be the maximum dose in the initial part of the trial. Pretty much every side effect I have dealt with has been explained by my doctor or APRN saying "it's probably from the trial drug". The exception, of course, is the skin rash which is almost a given with Cetuximab.
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@wpprescott Thank you! Appreciate the information very much. I'm really surprised how much higher the dosing is (my wife is currently on 800 mg daily) versus RMC-6236, which is at 300 mg daily in the current Phase 3 study.
I guess it's possible that the specificity of the Quanta molecules targeted at individual mutations allows the dose to be pushed higher than Pan Ras inhibition, which may impact more non-cancerous cells from a side-effects perspective.