GAME CHANGER - Mestinon (pyridostigmine) is a prescription medication (primarily used to treat myasthenia gravis) and i've been on it for 6 months now. I have 60mg pills - started 1/4 of a pill twice a day for a week, then 1/2 a pill twice a day for a week and now i'm on 1 pill twice a day. My doctor from Columbia Pres in NYC prescribed this to me and would like me to stay on it for a bit longer. I couldn't do anything without a cfs crash before i started it, now i can clean my house, my brain fog is gone and both Sunday and Tuesday i walked over 8 miles. I was tired afterwards, but... would you be? I skipped a day of meds by accident (visiting a friend) and i was very very tired w/o doing much. I understand this doesn't help everyone, but it is LIFE CHANGING.