My cancer was outside the prostate, the tumor had protruded into the seminal vessels and further spread to pelvis and one lymph node, Gleason 4+5
I did have a PSMA PET scan that showed the cancer in these areas. My PSA was 62.
Surgery was not an option given the spread of the cancer. I was put on a testosterone blocker and a second generation androgen blocker in drug,Nubeqa. Within 5 months my PSA had dropped to less than 0.10. I next had a pelvic MRI which revealed my tumor as shrunk back into the prostate, lymph node lesions had greatly decreased and the cancer in the bones was gone. I am now having radiation to destroy the remaining cancer, but still have to take the drugs I mentioned.
These treatments work, but the side effects are tough and you have to stay active and exercise to reduce the side effects.
This is my experience, hope this helps to answer your question and I wish your husband the best!