@greenshade, great questions. Mayo Clinic just updated their guidelines for the 2025 vaccine. Scroll about half way down the page to the section called Prevention
https://www.mayoclinic.org/diseases-conditions/coronavirus/symptoms-causes/syc-20479963
As the fall and winter months approach, Mayo Clinic is dedicated to providing the latest health guidance, ensuring everyone has the information needed to make informed decisions about their well-being.

EXCERPT
The 2025-2026 COVID-19 vaccines available in the United States include Moderna, Pfizer-BioNTech and Novavax. The vaccines are all approved for people age 65 and older. Each vaccine also is approved for younger people with a health condition that raises the risk of serious COVID-19 illness.

1. Moderna COVID-19 vaccine 2025-2026 formulas.
- Spikevax. This vaccine is approved for people ages 6 months to 64 years with a risk of serious COVID-19 illness and all people age 65 and older.
- Mnexspike. This vaccine is approved for people ages 12 to 64 years with a risk of serious COVID-19 illness and all people age 65 and older.

2. Pfizer-BioNTech COVID-19 vaccine 2025-2026 formula.
- Comirnaty. This vaccine is approved for people ages 5 to 64 years with a risk of serious COVID-19 illness and all people age 65 and older.

3. Novavax COVID-19 vaccine 2025-2026 formula.
- Nuvaxovid. This vaccine is approved for people ages 12 to 64 years with a risk of serious COVID-19 illness and all people age 65 and older.

Here's some additional information
- Comparing the differences between COVID-19 vaccines https://www.mayoclinic.org/diseases-conditions/comparing-vaccines
- Different types of COVID-19 vaccines: How they work https://www.mayoclinic.org/diseases-conditions/coronavirus/in-depth/different-types-of-covid-19-vaccines/art-20506465

COVID-19 is now in its sixth year, and the subvariants of the Omicron strain continue to drive infections in the United States. The good news is that vaccines, which have been updated each year since 2022, are still effective at preventing severe disease and hospitalization from COVID.