@amywells I was unfamiliar with PRAME so I did some research and found this article in Frontiers in Medicine:

Frontiers in Medicine; PRAME immunohistochemistry:

-- https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2023.1265827/full

In the first paragraphs of the Introduction, the above article explains what PRAME is, how and when it was discovered. At first I was a little confused as PRAME pertains to melanoma and cutaneous (skin) cancers but to a smaller degree it's found in the endometrium, ovaries, and the adrenal glands. This article focuses on a comparison of different types of testing but explains PRAME quite well.

@val64 is very familiar with this lab science and her recommendations are spot on. As for consent forms? Yes, the boards that approve studies (called Institutional Review Boards) are rigorous and requires that the perspective participant/patient be informed of anything and everything know that could happen. It doesn't mean that this will happen to you and as @val64 wrote it's possible to discern which side effects may be more likely (more common). There is a principal investigator indicated on the consent form so if you have questions then this is the person to contact.

As your options become less it's reasonable and good practice to offer clinical trials to patients. If I were you, I'd look into the clinical trials recommended by your oncologist and then do whatever trial you can get into sooner rather than later.