@edithmary I am also on Methylpred. I started with regular pred but the Methypred was far more effective, I am now down to 2.5 mg/day by alternating 2mg, 3mg every other day to make the effect of 2.5 mg/day. For the past month when I started at 3mg/day, I began to have signs of PMR upon waking. I normally need to use the bathroom each morning around 3 am. At that time I started to take 2 extra strength Tylenol. I did fine. As my body got use to to the 3mg/day, I started taking only 1 extra strength Tylenol. Five days ago I started my new methylpred dose of 2.5/day. Upon waking for the day (around 7am), I felt a bit more PMR symptoms in my neck and upper arms. Once again, as I need to use the bathoom around 3am each morning, I have upped my Tylenol back to 2 pills. Now when I wake up for the day around 7am my PMR symptoms are less. I will continue with the 2 extra strength Tylenol to let my body get use to this new Methylpred dose of 2.5. In about a week I will again decrease the Tylenol to 1 pill. This method seems to work for me. As per my Rheumy, the Tylenol is better than upping the Methylpred. As a side, I am experiencing changes in my body as I decrease the dose of the methylpred. My hot flashes are soaring. Regarding the difficulty of spliting the pills into quarters, I use a tweezer to place the pill in the pill slicer. When you have to halve the halfed pill, place the finished side of the pill to the slicer and then it will not crumble.