@marshgirl24 same experience for me. I had infiltrating lobular breast cancer in 2011. Had double mastectomies, lat flap reconstruction, eventual implants. Had 6 treatments iv chemo then tamoxifen until hysterectomy. Then on to letrozole for 8 years. Used estradiol suppositories for 1-1 1/2 years and had a recurrence of same exact cell type in original location …. Except since there was no breast tissue, it was in skin and chest wall. Following this conversation to see how many others had recurrence with estradiol use. And also, to learn if there is something to try that is 100% safe. Best wishes to you!!🤗