@mayblin Thanks for your encouragement Mayblin. Your research and studies you provide are a great support. My CTX reduction in bone turnover from BHRT far exceeded my greatest hopes. I am blown away by these dramatic results. I had been losing bone at a staggering rate from spine -2.8 to -3.5 in 4 years so my top goal was to stop the progression, which seems to have happened, and to get my CTX to at least below 400, the upper limit Keith McCormick mentions. I mentioned previously that my REMS score went from -3 to -2.6, so possibly a slight gain as well. These results are as good or better than effects of Bisphophinates which I've never taken. My functional medicine physician said it is one of the greatest CTX reductions she has seen from BHRT (with supplements) and at age 68! I will post my next dexa and REMS results in the new year. I wish you continuing success in your journey as well.