@cptrayes i have been diagnosed with RA since 2012. I initially began on Humira auto pen with methotrexate… the belief being there was a synergistic effect of the two drugs being more effective together than either was alone. But the MTX jacked up my liver enzymes. They kept decreasing the Mtx dosage and i developed antibodies to the Humira. So he switched me to Enbrel + MTX. That worked pretty well until the liver enzymes started to rise again. I went initially to injection of MTX rather than oral and that held things at bay - until it didn’t. So in 2020 I changed docs and started on Remicade infusions. No MTX. And still am on that program today.

so hang in and be willing to make changes…