@pamelaaci In what respect has NAC helped you with mucous. IFind that I spend about 30 minutes a morning clearing my upper airway then again around 11-12 noon more seems to accumulate...the biggest issue is in the late afternoon where I swear I could use one box of cubed kleenex then continues into the evening. I am on Dupixent, Breztri and Albuterol. I do pulmonary hygiene at leart 3 x per day, with my son helping with percussions. There are times that I need to use Hyper-Sal to really clear. I am active with gym time with a trainer 3x/week - strength training with 5-10 lb weights, leg presses at 40 lbs. So not frail, just can't seem to get rid of the secretions. Have had 3 valves placed in LLL and am on 02 , with resting 02 sats of 95! Its just the secretions and the "ugly cough" that has me down. Any suggestions. Have even consideed Rheoplasty. Dr Criner is my hero.....I think that I have read all his research papers and wish that he was my physician. Any suggestions would be appreciated. Thanx for listening!