@briarrose Hello, Lupron, or sometimes Zoladex, are given to premenopausal women to shut down ovaries and induce menopause in order to give an aromatase inhibitor, like anastrozole, that can be given only in post menopausal women. Yes, l think you should talk to your doctor about Kisqali, as it’s proven to reduce estrogen + her2 - breast cancer recurrence by about 28% in all stages. I think if you are stage 1 you might be elegible only if you are high risk (grade 3, high oncotype etc.)