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How many cores? And follow-up with results received

Prostate Cancer | Last Active: Sep 25 8:15am | Replies (17)

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I am concerned with the "Perineural invasion identified". Ironically, my Pi-rads 4 lesion is benign, but the doctor at Moffitt only took 1 core from the lesion itself. I am going to request an appointment at Mayo in Jacksonville for a second opinion, but here are my results. Thoughts? Thank you!

A. Right lateral base:

Benign prostatic tissue

B. Right medial base:

Benign prostatic tissue

C. Right lateral middle:

Prostatic adenocarcinoma, Gleason score 3+3 = 6 (Grade Group 1 ), involving 1 of 2 cores and 10% of submitted tissue.

Maximum linear length: 2 mm
Perineural invasion identified.

D. Right medial middle:

Prostatic adenocarcinoma, Gleason score 3+3 = 6 (Grade Group 1 ), involving 60% of 1 core .

Maximum linear length: 7 mm

E. Right lateral apex:

Prostatic adenocarcinoma, Gleason score 3+3 = 6 (Grade Group 1 ), involving 5% of 1 fragmented core.

Maximum linear length: 1 mm

F. Right medial apex:

Prostatic adenocarcinoma, Gleason score 3+3 = 6 (Grade Group 1 ), involving 70% of 1 core.

Maximum linear length: 8 mm

Perineural invasion identified.

G. Left lateral base:

Benign prostatic tissue.

H. Left medial base:

Benign prostatic tissue.

Additional deeper levels examined.

I. Left lateral middle:

Benign prostatic tissue.

Additional deeper levels examined.

J. Left medial middle:

Benign prostatic tissue.

Additional deeper levels examined.

K. Left lateral apex:

Benign prostatic tissue .

Additional deeper levels examined.

L. Left medial apex:

Benign prostatic tissue

M. Prostate, ROI #1, PIRADS-4:

Benign prostatic tissue

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Replies to "I am concerned with the "Perineural invasion identified". Ironically, my Pi-rads 4 lesion is benign, but..."

PNI is very common and usually not considered an adverse feature. Definitely get the second opinion and also talk to your urologist at Moffitt. You may be a candidate for active surveillance with only Gleason 6 cores. But two of the four have a high volume, which may be a concern.

Get a second reading of your biopsy too, ideally before seeing someone at Mayo. Johns Hopkins is a good place for that.

@justme129
Moffitt is considered from what I read as an outstanding cancer center. You mentioned Mayo Jacksonville for second opinion. I have been a patient at Mayo Jacksonville since 2006. It is where I had my DRE, MRI/Contrast, and my biopsies done. But I chose UFHPTI for my radiation treatment because Mayo Jacksonville could only offer photon radiation and I preferred proton.

I think but not sure if you contact Mayo Jacksonville and asked for second opinion you might be able to send them your medical records and get a second opinion. In my case Mayo Jacksonville did additional tests that you have had. They added Decipher and bone scan. When I got second opinion at UFHPTI they ordered, and I got PSMA.

I noticed your Gleason score of 3+3=6. Let me suggest you look up Gleason Scores and their meanings. A 3+3=7 is consider low score and you have lots of options. I am not a medical expert but having gone through this with a Gleason score of 3+4=7 I wish I had your score of 3+3=6 if that tells you anything.