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What to do after Tymlos (complicated)

Osteoporosis & Bone Health | Last Active: 6 days ago | Replies (17)

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Profile picture for anewyorker @anewyorker

Thanks to everyone for your thoughts.

Gently, you're going to be sorry you asked. I thought you raised some good points, so I went back and made a chart (it's the compulsive organizer in me) of both what meds I've been on and DEXA scores. You're quite right that I didn't improve on Prolia; the only med that's had an impact is the Tymlos (saints be praised).

I am totally bumfuzzled and without a clue as to what comes next. I really prefer to avoid Reclast, understand the concerns about Proolia, and don't see a perfect option. I will see what I can find out about Forteo as the only other viable option.

Here you go:
Treatment:
Raloxifene 60 mg daily from 1998 to 2006, discontinued due to blood clot
Alendronate 70 mg weekly from 2006 to 2010, discontinued due to duration of use with subsequent "drug holiday"
Denosumab 60 mg SC in February 2020, August 2020, March 2021, September 2021, March 2022, September 2022
Alendronate 70 mg weekly from March 2023 to October 2023 (discontinued due to GERD; compression fracture 10/23 after bad trip and fall)
Denosumab 60 mg SC in November 2023
Abaloparatide 80 mcg SC from January 2024 to present

DEXA spine T scores:
5/2010 -2.5 (after four years of Fosamax)
2/2020 -3.2
2/2021 -3.3
2/2022 -3.2
2/2023 -3.3
3/2024 -3.2 (not including L1 bec of compression fracture 10/2023)
2/2025 -2.6 (excluding L1)

Thanks so much for your help, everyone. I guess if there were a perfect option there would be no need for this forum. Maybe someday . . .

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Replies to "Thanks to everyone for your thoughts. Gently, you're going to be sorry you asked. I thought..."

@anewyorker I was a fosamex failure. Bone density decreased over 1 1/2 years with 3 compression fractures. Now on Tymlos for one year with no further decease in hip and increased bone strength in Lumbar spine. Not sure what to do next year though after I will need to be off Tymlos. Similar problem to yours.

@anewyorker
so glad you asked.
The Fosamax may have saved you a fracture from 2010 to 2020 because it stays on your bone for ten years or so. Denosumab is not effective. You can't take Evenity. From your experience with Fosamax, Reclast probably won't increase your bone density. Tymlos really works for you.
If you have segmental spine measurements, I'd be curious to see the numbers, especially on L1, because I want to blame Prolia,
but really on each segment to see how effective Tymlos really has been.
Reclast is much stronger than Fosamax, so you may reconsider. But otherwise I don't see much of a choice. Forteo is more effective in the spine. but another year of Tymlos would probably be a good choice.
Would your prescribing doctor agree to another year or to Forteo