I really appreciate your detailed explanation. The Sudafed recommendation came in handy. Unfortunately, I am one of those patients who reacts poorly to Trimix, with the prostaglandin/alprostadil ingredient causing significant pain during the erection and eliminating the pleasure of intercourse. I have asked my oncologist for a Bimix prescription to try, leaving out that chemical but also likely reducing the effectiveness. I'd rather not do without sex the entire two years I'm on Orgovyx and beyond that to recovery.