@gbear1953 Side effects vary a lot from person to person. And to be fair, no one is exactly doing big clinical trials to find the best protocol to switch from one of these to another -- it seems to be pretty much just a judgment call. So although the literature encourages you to ramp down on the old drug before switching to the new one at a low dose, I don't imagine it's likely to cause any serious harm to switch at higher doses. After all, these things largely flush out of your system in a week, so even if it's a week you regret, you can always drop the dose then.