You ask...I assume you mean a drop to < .2 after salvage radiation combined with the doublet therapy?

You say he is getting radiation therapy plus doublet...

I assume the radiation treatment is SRT to the prostate bed + Whole Pelvic Lymph Node

I assume the double is ADT +ARI though you don't say which agents, useful clinical data for the forum in responding. The 24 months is in the standard range for the clinical data you describe, his medical team may be thinking 36 but want to see the clinical data at 24, then decide.

The chemotherapy was not an issue...for me. Others may not voice the same sentiment. I was in good physical shape, that may be a factor.

Yes, lost my hair grew back.
Experienced fatigue, yes, still played basketball, rode my bike, worked out at the gym...
Some nails on the toes and hands turned black and blue, went away.
Did not experience neurotherapy
My taste buds took a hit, wife would ask what I wanted for dinner, my response, well, not sure as it tastes the same...

The infusions were every three weeks. With the drugs they give you to avoid nausea, you feel pretty damn good the first 24-48 hours, then you (I) crash for 72-96 hours and the next two weeks are "reasonable."

I did experience pretty extreme fatigue with the 4th infusion, no explanation, went away.

I travelled while on chemotherapy, WBCs weren't too bad.

So, yes, his PSA decreasing to < .2 with the radiation plus doublet therapy in the first three months would be an indicator of a longer PFS...how long, nobody can say.

Kevin