@garyhu Have a very honest talk with your oncologist(s) regarding Quality of Life vs. Longevity. I'm 74, a walking mass of arthritis, with lots of surgeries. My family rarely lives past 80, so my goal is a decent quality of life for 5-10 years. Oncologists are almost always focused on cure. My cancer is/was Gleason 7, N1M0 which means I had cancer in lymph nodes near the prostate but everything contained in the abdomen. I think another term is Oligometastatic, either Stage 3 or low Stage 4. The longer series of ADT is to allow more time for the combination of radiation and hormone therapy to weaken the cancer cells so they die when they try to divide and multiply. I have to weigh the possibility that some cells "escaped" during radiation and will show up later if I stop sooner....against the odds that I will be 77 or so when testosterone returns and I feel more normal again. Yes, ED is a sad outcome, and I tried Trimix shots but I have a reaction to the chemicals resulting in quite a bit of pain, so not a good option. Again, discuss your goals vs. the odds of the disease returning. My tests in May and August showed undetectable PSA and Testosterone.