I have been on Lupron every 3 months for a little over 2 years and have had no soreness after the shots. As for heart disease, I have been active all my life and continue to work out in a gym for ~3 hours 3 days a week and ride a recumbent trike (I have had some balance problems since the chemo I did last year and don't trust myself on a bike any more) for 20-30 miles 3-4 times a week. Rather than worry about heart disease, exercise! The other thing about exercise is that it dramatically helps my mental state and sleep. Based on my admittedly short experience, Lupron is good treatment and not to be feared.