Asked my Oncologist about it. Not part of protocol here as they are not confident at this point as to how to manage the results. Could ‘cloud’ the picture..

I’ve had the Signatura several times. It confirms negative cancer as well as my pet and Ct scans. It does not agree with my CA125 which is very high. Quite confusing.

It is quite confusing as it is just starting to be used in ovarian cancer. But to your point CA 125 is also not always a reliable marker. I had a CA 125 of 7 but had a recurrence in a lymph node that was picked up by a positive Signatera test and required surgery for removal. I now get Signatera for monitoring as well as CA 125 and now both are negative. Nothing easy for us ovarian cancer warriors.

My oncologist has given me a similar response to Laurelmarie’s doctor. (I am an endometrial cancer patient.)
But I hear that MSK uses circulating tumor/blood biopsies as standard protocol. My brain says that it’s another tool in the toolbox to try to catch recurrence quickly. Maybe it’s an insurance issue?

I am new to this site. Last year was diagnosed with stage 3 ovarian cancer and peritoneal cancer. Had 6 months of chemo and radical hysterectomy. CA125 is now under 4 and taking Lynparza.

I have a question what is this
Signature test? I will have to discuss with my Dr.

I am so happy to find this site.
Also anybody else taking lynparza.

Thanks for explaining the test.

Also you said you take Lynparza as well. I have been feeling pretty good on this drug but do have some side effects like tiredness. Also some GI issues.

Do you experience any of these?