I have recently been diagnosed with PMR and they have started me on 20mg of Prednisone daily. I know it's early yet "day 13" but i have had no relief for the pain yet. I to am concerned about mobility issues as my knees are very sore and stiff in the mornings and throughout the day. I usually take a couple of Tylenol which provides some relief. (Tylenol has been approved by my liver specialist and Prednisone by my Rheumatologist) I have the pain in my upper back, lower neck, arms , on the pain scale out of 10 I would give most days a 5 to 6, but the worse is in the "Right" shoulder, left shoulder is mild pain. This pain wakes me up at night, it's a sharp pain, out of 10 i give it an 8 and it can last a few hours . I now take a couple of Tylenol later at night before going to sleep (1:00am) This gets me through the night until about 7-8 am the next morning, I'm unable to make any plans as I have no idea how I will feel after being awake for an hour or so. Life is very frustrating right now and I'm not understanding why. I have spoken with my my Rheumatologist concerning and they have told me to be patient and stay the course, sometimes Prednisone takes awhile to kick in I'm being told . That was a week ago and i don't see her again until October 17th along with my monthly blood work that i will provide. Is there anyone out there having the same problem with the Prednisone not working, extreme pain in the right shoulder. I have also began reading and investigating a condition called Referred Pain as i have also been recently diagnosed with liver cancer. At this time it seems to be one of the lower level cancers but i will be seeing a specialist in the coming weeks and hopefully be cured. I'm also reading about another condition called Steroid resistant. Bad thing with all this is that there are two many rabbit holes, don't over read and let the doctors do there jobs.