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How long to does one stay on hormone therapy Orgovyx?

Prostate Cancer | Last Active: Sep 25 3:44pm | Replies (27)

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....I had to double check the shorthand 'n' meaning AND. Had it been NO seminal vessels some of the advice would have caveats.
For those reading this with prostate (likely) contained disease there is emerging information. One study found that those without the certain biomarker had no benefit with long term androgen deprivation therapy, 18-30 months [LATD/LTD], versus those on short term therapy 6 months, [STADT/STDT]. Those with the biomarker revealed an added benefit of disease free progression with LATD versus STADT. It was in the 15% range. It might be noted that the underlying data derived was before the general application of the newest technologies. [Dye enhanced 3T mpMRI, PSMA PETCT scans, (ultrasensitive PSA hallmarks?) and focused spot external beam radiotherapy {e.g. SBRT}] Speculation: The 15% difference may be less and essentially a toss-up for those willing or unwilling to get a marginally lessened progression benefit. This biomarker's discoverer is in search of commercialization opportunities,

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Replies to "....I had to double check the shorthand 'n' meaning AND. Had it been NO seminal vessels..."

The thing is, they discussed the fact that this is true with intermediate patients. So those with extensive PC do not benefit apparently.

As demonstrated below, intermediate risk patients who were biomarker negative did not benefit from short-term ADT. Conversely, those with a positive biomarker status had significantly decreased distant metastases rates when short-term ADT was added to radiotherapy (HR: 0.33, p< 0.001):

Here is an article from ASCO that actually discusses this
https://www.urotoday.com/conference-highlights/asco-2023/asco-2023-prostate-cancer/144902-asco-2023-development-and-validation-of-an-ai-derived-digital-pathology-based-biomarker-to-predict-benefit-of-long-term-androgen-deprivation-therapy-with-radiotherapy-in-men-with-localized-high-risk-prostate-cancer-across-multiple-phase-iii-nrg-rtog-trials.html