Wow... sorry to hear you've been through quite the ordeal. And I'm sure just to stress the uncertainty and also lack of answers has also created quite a bit of angst & anxiety in your life.

( Haven't started off with 2 full knee replacement surgery (fully replaced both last 9 months)and having to wait literally almost 6 years to get that recently completed ... also find out previously I had a rare IMMUNO blood disorder (Thrombocytopenia), I can identify with some of what you are going through...

I believe one of the major items you mentioned is that you have kidney disease. If I've learned anything over the last 3 years, it's the importance of the different organs within our bodies and I can tell you that the kidneys rank right up there near the top of the list for critical functions

Itchy skin is typically associated with toxin buildup in our body and them being excreted via our skin's pores. We do it via sweating regularly. There are many, many things that are a body does not react. Favorably to it could be medications. It could be certain foods. It could be certain chemicals. There is an extensive list and since different people are different... It is often hard to pin that down.

There is no question that in its many forms, from Rheumatoid Arthritis to Osteoarthritis, both are fronts for inflammation! And inflammation CREATES MANY MANY PROBLEMS in the human body when present and left unabated.

Inflammation of the nerves is MS! Inflammation also attacks organs! inflammation attacks the blood circulatory system. Inflammation is HIDDEN enemy number one!
Inflammation is the driving force behind most auto immune diseases. ( Because it attacks, altars and even destroys cells and cell membranes! )

Inflammation that I had from my swollen bad knees over the many years... is what caused my blood disorder! And my Osteoarthritis is what gave me problematic knees.

You appear to have kidney disease as well as major inflammation issues from your Arthritis... and I don't know how long you've had the Arthritis, but Arthritis comes with inflammation; it would seem that a lot of the symptoms you have are being derived from the effects of inflammation on other components of your body.

YOUTUBE EXCELLENT RESOURCE... There are many excellent videos available free on YouTube on inflammation, as well as the best natural foods that help fight inflammation. And I would hardly recommend that you visit YouTube where you can search for that key information. There's also hundreds and hundreds of videos on YouTube about many other health challenges and health conditions that you might find of interest.

DIETARY REVIEW...of exactly what you've been consuming as your main staple of foods with your doctors may be a very insightful endeavor because we are what we eat! Kidney disease does not typically develop overnight, and your body seems to be saying. It has major issues with the particular nutrients in your intake / diet, or chemical environment that you are around or have been in.

In many cases, our bodies respond pretty quickly to a correction in diet and/or environment. And often better nutrients provide the assistance our bodies needs in order to start healing itself or start improving.

HEMATOLOGIST... Usually are the folks that are involved whenever there's any question of whether or not an individual or patient might potentially have an immune base disease! They're blood doctors. And they typically direct the rest of the doctors, including surgeons because everything in the human body depends on the state of your blood. The blood is the key.. it typically has answers. Or can direct doctors to specifically find those answers. Most things in the human body show up in our blood.

I highly recommend you see a Hematologist asap. I don't let anyone treat me unless my Hematologist says so...

Wishing you answers...