bswpb: I went on Prolia 5 years ago as a last resort. No problems. Then my doctor said she was mandated by the health organization she works for (Sutter Health in Calif.-it's not an HMO but is starting to act like one) anyway, she was mandated to switch to a new biosimilar drug with the same active ingredient called Jubbonti. (It has only been on the market for 3 months. On their website Jubbonti brags about how we can expect the same good results as we get from Prolia but their drug is cheaper) Anyway, had a Jubbonti shot 5 weeks ago and it was a nightmare for me. Bladder inflammation, which I was put on antibiotics for, my intestines still aren't normal, and just a feeling of being unwell. Just wanted to give y'all a heads up. Biosimiliar drugs aren't identical, just the same active ingredient, but your body might react differently to a new formulation.