I just joinned, and I am delighted to participate in this forum. I have been reading AD literature for the last couple of years due to family history of ADs. I am not a physician or medical professional but was trained as a chemical engineer. I am going to start taking a very low dose of lithium orotate once I receive the shipment. Earlier today, I went through the recent Nature paper by Aron Liviu etal from Harvard and decided to explore this subject by some self-experimentation in a scientific way.
As we all know, safety is a paramont concern when taking any supplements so I searched low dose lithium long term toxicity in the medical literature but found little. There are well established renal toxicity when prescribed at very large dosage of 300 to 400mg of lithium carbonate which has very low bioavailibility. On the other hand, lithium orotate has very high bioavailibility due to the orotate ions help lithium ions get into cells, especially in the brain. Thus, how much lithium ions in the blood and how long they stay becomes important.

I searched the lithium orotate half life in blood (hours of 50% of lithium ion still remaining in blood after introduction) and found 24 to 36 hours, however, long term use increases half life to 48 to 64 hours. Thus, I think it will be a good idea to take lithium orotate every other day or every third days in stead of every day.

I sincerely welcome any discussions on this subject.