@rjack6618 - My neuropathy is from 4 inches below the knees to toes, all numbness, poor balance, zero pain (thankful!!). My knees are a mess and was getting cortisone shots every 3 months. The shots work for 6 - 8 weeks and the last 4 - 6 weeks prior to next shot was painful. Osteoporosis is a concern so now, the orthopedic surgeon will give me shots no earlier than 5 months apart and he is absolutely correct. Due to peripheral neuropathy and greater chance of falling, my knees can't be replaced. Voltaren cream does reduce knee pain along with Advil. On my end, the insurance will pay every 3 months, but it is more of medical concern. I'm holding off on the next shots until early Dec to get me through the holidays. Unfortunately, we need to time our abilities, activities like trips to availability of knee shots. Nonetheless, I keep moving the best I can, and as painful as it may be, I keep walking.