Methotrexate reacts differently with each and every person. I did not have any good experience with methotrexate or any other medication‘s for that matter so I’m not a good example. After taking methotrexate for a while it didn’t make me feel any better and I ended up very dizzy and it did not do anything for me either. Most people have no problems with methotrexate. My suggestion would be to discuss the situation you were having with MTX with your rheumatologist. My very best wishes to you going forward.