10 mg is usually just the lower dose starting point with an increase up to 20 - 25 mg per week. It usually takes 2-3 months to do any good if it is going to work for you. There are a lot of people it doesn't work for. Initially it worked for me and helped me get down from a high dose steroids for PMR/suspected GCA to under 9 mgs in 10 months. But then it stopped working and my steroid dose kept going up again due to a very high CRP. My doctor insisted that here was no problem with the methotrexate and there was something else. My blood cell count was all over the place and I developed anemia. Hospital emergency staff took me off methotrexate and my health improved over the next 8 weeks with blood cell counts returning to normal range. Please make sure you have regular blood tests and question your doctor about poor blood counts if they appear. My doctor should have picked up that my results were as bad as they were. He is normally very good but he has a faith in methotrexate that led him to be being less cautious then he should have been.