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Aromatase Inhibitors: Did you decide to go on them or not?

Breast Cancer | Last Active: Sep 22 2:13pm | Replies (1230)

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O my! What a dilemma we are in and my situation is definitely not good either.
On anastrozole 1 mg. daily since June 2025. Since then, my systolic blood pressure has never gone below 140...ranges are 140-152. The diastolic (bottom #) is good. These numbers are not severe but not me either. I am usually always below 130. During this time I have had 3 dose increases in my blood pressure medications and, so far, the increases are not bringing it down. Not to mention the low level (sometimes high) daily headache. I have also noted my platelet count is gradually decreasing. My high was 197 in June 2023 & over the past 3 months went done to 142 which is an abnormal result. My breast oncologist brushed this off...simply saying "platelet counts always fluctuate" as well as my cardiologist. He said "the numbers are OK, you don't need to see hematology".
I also have ischemic heart disease which is NOT a good thing with these AIs. Small possibility of a heart attack or stroke. My cancer was "caught early" but that's meaningless for a re-occurrence. Oncotype 14, no radiation or chemo. Bilateral mastectomy (cancer in both breasts). 1 positive lymph node out of 12. My blood pressure and headaches are my main concern. Thinking of exemestane. I am already on Claritin (cetirizine) for a year for allergies. I could live with the petechiae vs. H/A's and increased B/P. But my oncologist said "all AIs have side effects, if you want it, I can change the medication". I said "I will give it more time"...not knowing what I will experience with exemestane. Maybe I am just going in circles here...any thoughts BC support team?

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Replies to "O my! What a dilemma we are in and my situation is definitely not good either...."

I would give Exemestane a try. Take it every other day with Claritin to see if it tolerable. If you don't feel so bad, then increase to 2 days on, one day off. I'm now taking it every day and the petechiae is very light. Im thinking of getting off Allergra soon to see if it makes any difference.

BTW, according to American Society of Clinical Oncology (ASCO), taking exemestane 3 times a week is non-inferior to taking every day.https://dailynews.ascopubs.org/do/reduced-dose-exemestane-noninferior-standard-daily-dose-postmenopausal-women-early-er
I think AIs are not only for prevention of cancer recurrence but also for prevention of metastasis because they starve rogue cancer cells in the blood.

Sending you love and hugs. I’ve been on anastrozole since 2021. I have my own wrist BP cuff. I take my own blood pressure at home. It’s normal if I’ve been deep breathing and sitting in my chair for 15 minutes—feet on the floor. It’s always high when I’m at my oncologist’s office. Having or having had BC and being concerned about recurrence is stressful every day! I long for the life I used to have.

As for headaches, my husband gets them. My chiropractor mentioned that headaches usually come from the neck and stress. (My husband worries about me.) I have my husband sit on a chair, and I stand behind him and press on pressure points on both sides of his neck and on each side of his spine down to his scapulas. I rub his tense scalp, and rub his neck and shoulders. His headache is always better and completely gone about fifteen minutes later. I wish I could do this for you❤️💕❤️