As others have said, there's nothing you can do about the ultra-high CAC score. Sounds like you are doing what you are supposed to do. Increase the statins and get the LDL down to 50% if possible (mine's still up around 70). The Zetia is supposed to quicken the pace of dropping the LDL. Keep the sugar intake down (to avoid complicating things if he gets diabetes), and keep a close eye on BP - if it regularly creeps up over 130/80 see the cardiologist for advice. I'm glad I did the CTA (with contrast dye) as it gave me some reassurances about the heart situation, but with a high CAC score, there could be stenosis (blockages) anywhere in the vascular system, which is a bummer still of course. I'm now checking my neck and head with TDC (Doppler ultrasounds of the head and neck). Knowing what's going on with blood flow there is as crucial as it is in the heart area (to avoid a stroke and/or blindness from blockage or occlusion of arteries leading into the brain). If its bad I'll do another CTA for that region and take whatever action I need to take. Good luck!