I hadn't heard that oncotype doesn't apply to lobular cancer but I do know from all my research that most of the data and research isn't focused on lobular cancer since only 15% of women have this type of cancer. Honestly I am six months into to taking letrozole. I had stage 1A lobular - no lymph node involvement Grade 2 cancer. So I did bilateral mastectomies to reduce chance of it coming back in the other breast. I spoke with my oncologist and she said I had a 8% chance of long term re-occurance while taking letrozole and it is the best choice for lobular cancer. I have some joint pain and hot flashes and have had hair thinning. I take Bonafide Revere for vaginal dryness and that works great. I find that exercise is the best medicine for the joint pain and stiffness. Get into a gentle yoga class and lift weights for your bones. I have some osteoporosis in my hips and they immediately wanted me to do Prolia but my GP and breast surgeon said no - they both said lift weights and take calcium and D and magnesium and see where things stand in two years. I also read a study someone on this site shared that said people could take letroxole every other day with the same result but experts say the study had too small a sample. The fact is it has a 48 hour life in your body so taking it every day means you have higher levels than you might need? I would like to see some experts weight in on this. I am also 70 - I am very fit and active but I feel for those of us who feel torn between risking a return of cancer or living with horrible side effects for 5 years minimum. More research needs to be done for lobular cancer. Is anyone monitoring this site from Mayo able to answer our questions?