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Low progesterone and high SHBG

Women's Health | Last Active: Sep 23 10:47am | Replies (10)

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"I’m so sorry you’re dealing with all of this — it’s exhausting when your body feels off and doctors don’t give you real answers.
Have you seen your free testosterone and free estradiol numbers? Total labs and ‘normal’ ranges can be misleading — they may look fine on paper but not be right for you. High SHBG usually connects more with testosterone and estradiol, and less so with progesterone.

Also, thyroid issues can look almost identical to hormone problems — brain fog, fatigue, weight changes, sleep struggles. A full panel (TSH, free T3, free T4, TPO antibodies, and thyroglobulin antibody) might help rule that out.
It’s possible to be in perimenopause in your early 30s, but it’s definitely worth making sure thyroid and other imbalances aren’t the main cause first. It sounds like you're seen a few different doctors already. You might just have to keep digging deeper, to find a doctor who will help. Do you belong to any perimenopause group boards like FB. Reddit or podcasts? You could post your questions there. These are women who are feeling the same as you and going thru the same symptoms.

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Replies to ""I’m so sorry you’re dealing with all of this — it’s exhausting when your body feels..."

Thanks so much, I have only had total labs, not free levels - I'll request during my appointment next Wednesday. I had full thyroid panel including antibodies which came back normal.
I have joined the groups on reddit, but for some reasons this post keeps getting deleted by moderators.

Search for a physician who specializes in hormone replacement therapy. They run a completely different lab panel.