I don't have an autoimmune disorder that I'm aware of; however, after taking Evinity for a year, my doctor suggested I take Prolia for a year. Two injections every 6 months. I agreed since I didn't have any known reaction to Evinity. Shortly after my Prolia injection, I developed a terrible rash that has now spread to my head, arms, back, and some areas of my chest. It's very itchy and bumpy, and nothing seems to help. I'm taking antihistamines (I've tried several), plus I've tried everything topical and a month on Decadron. No relief. I'm thinking it may not clear up until the 6 months that the injection is in my system. Everyone is different. You may not experience this side effect, but I thought I'd share so you are aware.