Yes! I’ve been on letrozole for 5 months and have lost hair (now very thin all over), gained weight (15 pounds) on formerly slim body , and developed edema in feet and legs that has also resulted in spider veins, varicose veins, and purpura on legs and feet. Oncologist is unsympathetic. Will prescribe one of the other AIs but says I might be changing “nuisance” side effects for “serious” side effects. Discouraging!