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Bone turnover markers (CTX and P1NP): do you have a baseline?
Osteoporosis & Bone Health | Last Active: Sep 20 11:58am | Replies (240)Comment receiving replies
Hi @glojo, I agree with @gently’s view. Looking at your results through the lens of premenopausal reference ranges from Quest, your P1NP shows bone formation is quite active, which is great. Bone turnover seems a bit more toward resorption than formation - not extreme, but consistent with what we often see in osteoporosis.
If yiur lumbar spine started normal 20 years ago, your current T-score of –3.7 suggests an average loss of about 2% per year, which is in line with typical postmenopausal bone loss. For context, my spine loss was higher at ~4% per year between age 53 and 59, but I don’t have baseline markers to compare, so it’s just a rough reference. Starting an anabolic treatment could help rebuild bone and improve strength.
Do you have a TBS score? Also, would you share the reason behind choosing Evenity over a PTH analog like Tymlos or Forteo? Thanks!
Replies to "Hi @glojo, I agree with @gently’s view. Looking at your results through the lens of premenopausal..."
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TBS is 1.141, which is not great. Also had a vertebral fracture assessment which is excellent. The endo, who is unaware of my bone markers, felt that Evenity would result in a faster response, especially in the spine; however, his resident fellow, who visited with me first, insisted on Forteo. Personally, I would be more comfortable with Forteo, if for no other reason than it’s been around longer!
I will also add, for anyone who might be interested, that I have had two REMs a year apart that show -1.8 T score in the spine and -2.3 in the femur, with a fracture risk of 3-5%,.just to add more drama and confusion! I don’t want to stir up a discussion on this thread about REMs, but I do find it all quite fascinating.
Based on my DXA, I was extremely surprised at the bone markers, especially the P1NP, and although high, the CTX was lower than I expected. I am not naive about all of this, but I am somewhat encouraged that my blasts are active at least. Maybe not enough to compensate for the breakdown, but not as dire as I had imagined.