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Methotrexate risks versus inflammation risks

Autoimmune Diseases | Last Active: Sep 29 11:13am | Replies (11)

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I spoke to a fabulous NHS pharmacist this morning who had been told to put me on MTX, and asked her this question. She couldn't answer it but she did agree that it seemed unwise to take methotrexate when I'm symptom free. So she has referred me back to the Rheumatologist for ultrasound investigation of whether i do or don't have active inflammation going on in my joints and so I can ask the question of a Rheumatologist. That'll probably take 2 months to happen, which will give the supplements more time to work. I've bought the test kit already to take another blood sample to get a third CRP reading which will tell me if the CRP is going up, down, or stable. Up, I'll take MTX, down I'll stick with the supplements, level, I'll do what the Rheumatologist tells me to do.

Apparently there are 1 million people in the UK on methotrexate but there's no doubt it's a nasty drug. Taking it for cancer to save your life is one thing. Having blood tests every 3 months for the rest of your life to take it when you don't have any symptoms, only blood markers, is quite another!

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Replies to "I spoke to a fabulous NHS pharmacist this morning who had been told to put me..."

@cptrayes i have been diagnosed with RA since 2012. I initially began on Humira auto pen with methotrexate… the belief being there was a synergistic effect of the two drugs being more effective together than either was alone. But the MTX jacked up my liver enzymes. They kept decreasing the Mtx dosage and i developed antibodies to the Humira. So he switched me to Enbrel + MTX. That worked pretty well until the liver enzymes started to rise again. I went initially to injection of MTX rather than oral and that held things at bay - until it didn’t. So in 2020 I changed docs and started on Remicade infusions. No MTX. And still am on that program today.

so hang in and be willing to make changes…