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DiscussionLooking ahead after Tymlos: Reclast, Evenity or HRT?
Osteoporosis & Bone Health | Last Active: Sep 20 9:57am | Replies (113)Comment receiving replies
Replies to "Love your last paragraph. One would think that however most of us are women and the..."
Osteo Meds are 2 distinctly different classes; this is important. Here ( below is a paragraph from that article) in a nutshell is a great deifinition from : Skeletal responses to romosozumab after 12 months of denosumab - PMC
Please pay particular attention to the last sentance about sequencing. Bone forming drugs are not as effective ( but still work to some degree) if taken after bisphosphantes.
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".....Antiresorptive drugs and bone‐forming agents are distinct classes of therapies for treating patients with osteoporosis.( 1 ) Estrogen receptor activators, bisphosphonates, and denosumab are anti‐remodeling drugs that reduce bone resorption and formation, increase bone mineral density (BMD), improve bone strength and reduce fracture risk, but they do not restore the disordered trabecular microarchitecture found in patients with postmenopausal osteoporosis.( 2 ) In contrast, bone‐forming agents stimulate bone formation, resulting in large increases in BMD and improved bone structure, and have been shown to be more effective at reducing fracture risk than oral bisphosphonates.( 3 , 4 , 5 , 6 , 7 ) Based on these data, bone forming agents are recommended as appropriate initial treatment for patients at very high risk of fracture.(..."
This should help you identify what is best for you based on your fragility state.
Now that said, bone forming drugs have unique charatieristics. Forteo and Tymlos build mostly trabecular bone and can in some cases ( my case) decrease cortical bone. Spine is mostly trabecular bone so if you are more concernered with spine issues, then either of those could be considered. I persoanlly had mutilple fractures in my feet which is mostly cortical bone. Therefore for my situation, Evenity is being used after tymlos to rebuild cortical bone. Hope this helps. Meanwhile I advise you read Great Bones by McCormick for further infomration to help identify cause for the osteo and help support your recovery. ( In my case I had super high urine cal lost, high homocysteine, high vitamin D,- also i had to stop drinking softened water which was processed with salt which compounded bone loss- all of these had to be brought into balance to effectively allow the drugs to work. I had corrected my diet and sleep schedule also. Low sugar no caffeine, low acid foods no alcohol lots of veggies ) Sending postive energy for your research, decsiison and recovery. You can do it!! God bless.