@sl303 Agree with you completely!! All of these osteo drugs have side effects, some quite serious, and no one can tell how their bodies react until it's too late. The risk of cancer, heart disease, stroke, blood clots, dementia and other biologic events increases anyway with age alone. To me HRT, replenishing a natural hormone your body has lost, makes much more sense, especially given that HRT actually protects against all of those things! If only we knew then what we know now.....and also 90% of doctors who are still afraid for whatever reason to prescribe HRT would update their education on all of the studies which show the benefits of HRT, it wouldn't be such a struggle. The struggle is real.

I'm actually not clumsy; this is the backstory. But over the past 15 years, I've fallen more than a few times. (Trying to prevent a dog fight when my dog was leashed but the other not, walking in the park with over grown grass and falling in a gopher hole, son-in-law filled the ice chest with ice to get on the boat and I didn't see the ice that he left on the floor) But after each fall, my primary care doctor would say, "Even with your osteoporosis your bones are stronger than we thought." My gynecologist, many years ago, said that there are studies to suggest that estrogen actually improves the "integrity" of the bones. I took that to mean the quality. After being on Forteo for 2 years, (years ago) my doctor wanted to transition me to Prolia to "keep what you've gained." (This was all back when I was in my early 60s and Prolia had just hit the market.) I said, "no thanks," and went on ERT (estrogen only, was happy I had a hysterectomy and could skip the progesterone) For the next 8 years, at every 2 year DEXA scan, my bones did not lose mass. Then, after 8 years I got breast cancer, Stage 1, non-invasive, and the oncologist made me quit the estrogen. My last 3 DEXA scans show a decline. So the reason for this post is to suggest that I believe that estrogen is fabulous for your bones, if you feel comfortable taking it. I'm do not regret having the estrogen patch all those years. I agree with sl303, I may have gotten breast cancer anyway. My quality of life was worth something and my bones benefitted from it. After b/c I was talked into starting Prolia. I was on it for 5 years and did fine. THEN my health organization switched to Jubbonti, with the same active ingredient, only on the market for 3 months, and my life has been a nightmare of side effects since my injection in August. I'm only mentioning this because if your healthcare provider pontificates how Prolia & Jubbonti are biosimilar don't necessarily believe your body won't react differently.