@wangling @scoop I spoke to Dr. Addrizzo today at NYU. I have this pesky staph aureus colonization that seems likely to stay. Already tried hitting it with 28d of doxy and It came back a month later. I am nervous about leaving it to fester but also worried about drug resistance happening. Dr. Addrizzo said it's very hard to get rid of and usually comes back so choosing not to treat it unless I feel bad, which right now I don't. All that to say, she recommended I participate in the Ensifentrine trial right away. She thinks it will help with the inflammation so I'm going to start the screening process etc.,

After reading about Bresocatib, I feel more comfortable with the idea of the Ensifentrine mostly because it's inhaled—going directly into the lungs and doesn't have the side effects involving the teeth and skin which concerns me. I'll keep you both posted. @wangling did you end up starting the trial after all?

My only hesitation with participating is that I might get placed in the placebo group and then I won't be getting the drug at all but I suppose if the staph starts wreaking havoc, I'll just get put back on antibiotics either way.

There's another trial that they aren't recruiting for yet called Airtivity (Boehringer Ingelheim)
It's also a once a day tablet, similar to Brensocatib.
Trial: https://clinicaltrials.gov/study/NCT06872892