Regarding "all drugs", I know NSAIDs are evil and most corticosteroids have irksome side effects. I have collagenous colitis; my diet controlled it for 7 years until I got covid two years ago followed by norovirus (a sucky year). I also have celiac and am sensitive to a lot of things, such as preservatives in food. Budesonide is a designer corticosteroid that is mostly localized to the intestines, so has a lot fewer side effects than most meds. The main thing that hits my GI tract is stress, but a few months of budesonide during bad flares helps tamp down my autoimmune reaction. It is also prescribed for Crohn's.