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You can ask the doctor if famotidine would be good enough instead of the Nexium. Taking a break for 2-3 days doesn't sound like a good idea because it can cause an acid surge. Maybe 1 day wouldn't be a problem, but 2-3 days might cause it. So, if you do stop for a day maybe he'd need to take famotidine on the day he doesn't take Nexium.
Another option is to check if the dosage can be reduced and still be efficient enough for his needs.

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Replies to "You can ask the doctor if famotidine would be good enough instead of the Nexium. Taking..."

Thank you very much ! I really hope that it works, it's so difficult trying to guess how he feels or if something is wrong because he can't tell us. Thanks for taking time to answer!