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Was your endometrial cancer tested for mutations in the gene POLE?

Gynecologic Cancers | Last Active: Sep 18 4:11pm | Replies (45)
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Thanks for that explanation. I also did an extensive genetic test once I had a confirmation of cancer (otherwise would have been out-of-pocket). I skimmed it for red flags (no doctor reviewed it with me), but I'll go back and look if it's in there?

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Replies to "Thanks for that explanation. I also did an extensive genetic test once I had a confirmation..."
val64 | @val64 | Sep 16 11:20am

If you had a next generation sequencing (NGS) panel done on the tumor tissue, POLE should have been one of the genes included. But if you had a genetic test done on your blood looking for inherited mutations, that won't tell you what you want to know. (There are also "liquid biopsies" where they take blood, remove the blood cells, and sequence the free DNA in the blood, which may include "circulating tumor DNA (ctDNA)". Depending which test, that might detect POLE mutations from the tumor. But these tests only sometimes work.)

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