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Was your endometrial cancer tested for mutations in the gene POLE?
Gynecologic Cancers | Last Active: Sep 18, 2025 | Replies (45)Comment receiving replies
I was NOT tested for Pole, but I was for a number of MMR statuses. I don't know why I was not. But I will ask in November when I have my nine months check up. I would imagine that the decision to do so is determined by the lab/pathologist? Or is it the surgeon?
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POLE testing is not done routinely in the US. The NCCN guidelines, which list recommended tests and treatments, suggest POLE testing. BUT they do not change treatment recommendations based on the results, unlike in the UK or Canada apparently. Probably because of this, insurance companies won't pay for it for patients at their initial diagnosis. They will after a recurrence. (Hospitals will happily perform any test that insurance will pay for.)
So, just like when I originally started this thread 3 years ago, if you want a POLE test, you have to beg and pay for it yourself.