Hi @janieben.

I was on PPIs daily for over a decade. The price I paid was that it became one of two drugs (the other being NSAIDs) that are known triggers for microscopic colitis. So there’s that.

Because that condition was so horrendous I made the difficult transition to Pepcid - aka Famotidine 20mg. Skip to the end of the story and that drug works just fine - now. But weaning off PPIs is not easy. Lots of tums and temporary diet change minimizing foods with high contents of fats and spices and alcohol and everything you know turns up your GERD, including reducing quantity of food in a single meal. . I took Pepcid twice a day for quite a while. And I slept with my head and shoulders raised.
But eventually for me it all smoothed out. I am on a maintenance dose of the steroid for the Collagenous Colitis. Bad that I need it - good that it is available. But Pepcid and managing my diet controls GERD.
Good Luck!!!