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Chronic Pain | Last Active: Dec 9, 2025 | Replies (36)
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Do you have to stop percocet to use low dose naltrexone? I have heard about naltrexone,but my doctor said he didn't think it would work for me since I have been taking percocet and can not just stop easily.
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""You must never take naltrexone and Percocet (oxycodone and acetaminophen) at the same time, as this can cause a serious and potentially dangerous reaction. Naltrexone is an opioid antagonist, meaning it blocks the effects of opioids like the oxycodone in Percocet.
Here is what you need to know about the interaction:
Precipitated withdrawal: Naltrexone can "kick off" any opioids that are already attached to your brain's opioid receptors. This immediately triggers severe and sudden withdrawal symptoms, known as precipitated withdrawal.
Withdrawal symptoms: Precipitated withdrawal is an intense, unpleasant experience that can include nausea, vomiting, chills, diarrhea, and intense body aches.
Overdose risk: Taking Percocet while on naltrexone will prevent you from feeling the opioid's effects, such as euphoria or pain relief. If you try to overcome this blockade by taking a larger dose of Percocet, you risk serious injury, overdose, coma, and even death. ""